Does Recombinant Human Bone Morphogenetic Protein-2 Use in Adult Spinal Deformity Increase Complications and Are Complications Associated With Location of rhBMP-2 Use?
نویسندگان
چکیده
Shay Bess , MD , * Breton G. Line , BSME , † Virginie Lafage , PhD , ‡ Frank Schwab , MD , ‡ Christopher I. Shaffrey , MD , § Robert A. Hart , MD , ¶ Oheneba Boachie-Adjei , MD , Behrooz A. Akbarnia , MD , ** Christopher P. Ames , MD , †† Douglas C. Burton , MD , ‡‡ Vedat Deverin , MD , §§ Kai-Ming G. Fu , MD , ¶¶ Munish Gupta , MD , Richard Hostin , MD , *** Khaled Kebaish , MD , ††† Eric Klineberg , MD , Gregory Mundis , MD , ** Michael O’Brien , MD , *** Alexis Shelokov , MD , ✝ and Justin S. Smith , MD, PhD § ; International Spine Study Group ISSG
منابع مشابه
Does recombinant human bone morphogenetic protein-2 use in adult spinal deformity increase complications and are complications associated with location of rhBMP-2 use? A prospective, multicenter study of 279 consecutive patients.
STUDY DESIGN Multicenter, prospective analysis of consecutive patients with adult spinal deformity (ASD). OBJECTIVE Evaluate complications associated with recombinant human bone morphogenetic protein-2 (rhBMP-2) use in ASD. SUMMARY OF BACKGROUND DATA Off-label rhBMP-2 use is common; however, underreporting of rhBMP-2 associated complications has been recently scrutinized. METHODS Patients...
متن کاملComplications of Anterior Cervical Fusion using a Low-dose Recombinant Human Bone Morphogenetic Protein-2
OBJECTIVE There are several reports, which documented a high incidence of complications following the use of recombinant human bone morphogenetic protein-2 (rhBMP-2) in anterior cervical fusions (ACFs). The objective of this study is to share our experience with low-dose rhBMP-2 in anterior cervical spine. METHODS We performed a retrospective analysis of 197 patients who underwent anterior ce...
متن کاملReply to "A critical review of recombinant human bone morphogenetic protein-2 trials in spinal surgery: emerging safety concerns and lessons learned".
BACKGROUND CONTEXT Increasingly, reports of frequent and occasionally catastrophic complications associated with use of recombinant human bone morphogenetic protein-2 (rhBMP-2) in spinal fusion surgeries are being published. In the original peer review, industry-sponsored publications describing the use of rhBMP-2 in spinal fusion, adverse events of these types and frequency were either not rep...
متن کاملQuality-of-Life Outcomes following Thoracolumbar and Lumbar Fusion with and without the Use of Recombinant Human Bone Morphogenetic Protein-2: Does Recombinant Human Bone Morphogenetic Protein-2 Make a Difference?
Design Retrospective study. Objectives (1) To investigate the quality-of-life (QOL) outcomes in the population undergoing lumbar spine surgery with versus without recombinant human bone morphogenetic protein-2 (rhBMP-2); (2) to determine QOL outcomes for those patients who experience postoperative complications; and (3) to identify the effect of patient characteristics on postoperative QOL outc...
متن کاملUse of Recombinant Human Bone Morphogenetic Protein-2 in the Treatment of Degenerative Spondylolisthesis.
STUDY DESIGN A questionnaire survey. OBJECTIVE To report the current use of recombinant human bone morphogenetic protein-2 (rhBMP-2) in lumbar fusion procedures for the treatment of degenerative spondylolisthesis (DS), and identify associated factors including fusion technique, surgeon location, surgeon specialty, or surgeon practice model. SUMMARY OF BACKGROUND DATA The prevalence of rhBMP...
متن کامل